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ARTICLE
Year : 2013  |  Volume : 1  |  Issue : 2  |  Page : 61-65

Antibacterial effect of kutaj bark (Holarrhena antidysenterica Wall.) with respect to Enteropathogenic Escherichia Coli (EPEC)


Asst. Professor, Dept. of Dravyaguna, Mahatma Gandhi Ayurved College Hospital & Research Centre, Salod (H), Wardha, Maharashtra, India

Correspondence Address:
Gawhare Vikesh Sudhakarrao
Asst. Professor, Dept. of Dravyaguna, Mahatma Gandhi Ayurved College Hospital & Research Centre, Salod (H), Wardha, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


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As stated in Ayurvedic texts Kutaj bark mainly useful in treatment of diseases like diarrhoea, dysentery etc. E-coli is most dangerous bacteria causing diarrhoea. Ayurveda has included all the microbes under the heading 'Krimi'. Bhavaprakasha Nighantu affirms, Kutaj bark having Atisaraghna and Krimighna property. Hence Kutaj bark having action on bacteria (Krimi) may have action on Enteropathogenic Escherichia Coli (EPEC) causing diarrhoea. So it is necessary to do the physicochemical standardization of Kutaj bark, to study its antibacterial activity on EPEC (In-vitro), to determine minimum inhibitory concentration of Kutaj bark for antibacterial activity against EPEC. Materials used are self collected sample, clinically isolated EPEC. Method used for antibacterial susceptibility is disc diffusion method. After study result came are, foreign matter is negligible, moisture content is 7.65%, total ash is 4.54, acid insoluble ash is 0.5%, water soluble ash is 5.67%, water soluble extract is 32.35%, alcohol soluble extract is 31.40%. Kutaj bark shows the antibacterial activity against EPEC in methanolic extract having MIC value 2.0gm/10ml.


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