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ORIGINAL ARTICLE
Year : 2019  |  Volume : 7  |  Issue : 1  |  Page : 20-27

In vivo anticancer activity and toxicity of Ayurveda compound W.S.R. to leukemia


Department of Agad Tantra, National Institute of Ayurveda, Jaipur, Rajasthan, India

Correspondence Address:
Dr. Monika Sharma
Department of Agad Tantra, National Institute of Ayurveda, Amer Road, Jaipur 302002, Rajasthan.
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/JISM.JISM_2_19

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Introduction: A diseased caused by an uncontrolled division of abnormal cells in any tissue of any organ of the body is called cancer. There are various types of cancers on the basis of primary abnormal growth in tissues. Leukemia is a type of cancer of blood, which is caused by the rapid production of abnormal white blood cell. In Ayurveda, the reference of the cancer and blood cancer is found indirectly under the heading of Arbuda (cancer) and Rakta Arbuda (leukemia), respectively. In Ayurveda, there are so many herbo-mineral drugs that are useful in treating cancer. Aims and Objectives:
  1. To study the in vivo anticancer (blood cancer) activity of Ayurveda compound.
  2. To compare the toxicity of Ayurveda compound with injection/tablet arsenic trioxide.
  3. To evaluate, elaborate, and discuss the etiology of leukemia as per Ayurveda.
Materials and Methods: An in vivo study was conducted in Institute of Biomedical and Industrial Research. The in vivo antileukemic effect was carried out by using benzene-induced (carcinogen) model in Swiss albino mice and the acute toxicity study was conducted according to fixed single-dose toxicity. The herbo‑mineral drugs has been prepared by using purified arsenic (arsenic trioxide), Vinca rosea, and Urginia indica to study in vivo anti-leukemic effect and toxicity. This study was conducted according to organisation for economic co-operation and development Guidelines 423 and the antileukemic activity was carried out by benzene-induced leukemia in albino mice after animal ethical clearance. Result: The highest dose of the test drug (2000mg/kg) in the acute toxicity study shows minimal adverse effect of toxicity on liver and no adverse effect was found on kidney and spleen. The result was found better in study group 1 having myelocytic leukemia than study group 2 having lymphocytic leukemia. Conclusion: The effect of study drug shows good antileukemic activity, although standard drug was found better than study drug. Overall, the study was found safe and effective on blood cancer.


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