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REVIEW ARTICLE
Year : 2017  |  Volume : 5  |  Issue : 2  |  Page : 106-110

Role of Toxicogenomics as an alternative for animal studies


1 Associate Professor, Department of Agadatantra, Mahatma Gandhi Ayurved College, Hospital and Research Centre, Salod (H.), Wardha, India
2 Professor, Department of Agadatantra, Mahatma Gandhi Ayurved College, Hospital and Research Centre, Salod (H.), Wardha, India
3 Assistant Professor, Department of Agadatantra, National Institute of Ayurveda, Jaipur (Rajasthan), India

Correspondence Address:
Nilima Wadnerwar
Associate Professor, Department of Agadatantra, Mahatma Gandhi Ayurved College, Hospital and Research Centre, Salod (H.), Wardha
India
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Source of Support: None, Conflict of Interest: None


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Technology in medical science is developing according to the need of health assessment. In medical research, animals are used for preclinical and toxicity studies for exposure and risk assessment as well as for prediction of toxicity. Current toxicological research concentrates on identifying hazards of chemical compounds and assessing risks of human exposure. These assessments are based on toxicological tests, most using animals as models for man. During such kind of studies, there are several issues due to which animal studies are not sufficient as there is lack of sufficient screening data and basic short-term in vitro or animal-bioassay data on toxicity or carcinogenicity of the compound. There is lack of information or inconsistent information about effects on humans and paucity of accurate information on human exposure levels. These issues are overcome by Toxicogenomics. It is an emerging area of toxicology that examines how the genetic make-up of an individual makes them more or less susceptible to toxicity and exposure related diseases. It is a field of science that deals with the collection, interpretation and storage of information about gene and protein activity within particular cell or tissue of an organism in response to toxic substances. In toxicogenomics, microarrays allow for study of all toxicological endpoints in a single assay. Traditionally in animal studies, we need to study an agents carcinogenicity, mutagenicity, reproductive toxicity, immunotoxicity, neurotoxicity, and endocrine toxicity in separate assays. The fact that groups of chemical with a common toxicological mechanism produce a characteristic pattern of gene expression means it may be possible to discern the toxic potential of an agent quickly and cheaply. It can prevent animal toxicity testing, thereby it will prevent from ethical issues regarding animals and their survival.


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