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REVIEW ARTICLE
Year : 2018  |  Volume : 6  |  Issue : 4  |  Page : 195-199

Advanced protocols for in-vivo evaluation of herbal anticancer drugs: A Review


1 Assistant Professor, Department of Rasashastra and Bhaishajya Kalpana, Mahatma Gandhi Ayurved College, Salod (H) Wardha, Maharashtra, India
2 Professor, Department of Rasashastra and Bhaishajya Kalpana, YMT Ayurved Medical College, Kharghar, Navi Mumbai, India

Correspondence Address:
Mujahid B Khan
Assistant Professor, Department of Rasashastra and Bhaishajya Kalpana, Mahatma Gandhi Ayurved College, Salod (H) Wardha, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


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Anticancer herbal drug development is based on in-vitro as well as in-vivo screening. The aim ofthis review is to study the advanced protocols for screening new potential herbal anticancer formulations ingested orally or applied locally. New anticancer herbal drugs are either designed for tumor specific targets based on a biological rationale or are generated by large scale drug screening programs. More than 350 tumors, covering a broad spectrum of tumor types. Only the most sensitive & target expressing tumors are selected for in vivo studies .Herbal extracts showing positive effect in-vitro have to undergo in-vivo testing. According to NCI, for large scale in-vivo testing recently Mouse Tumor Homograft, Hollow Fiber Assay, Human Tumor Xenograft mouse model and Genetically Engineered Mouse Model(GEM) are used. For in vivo study, prepared immune deficient species of nude/scid mice, rats & hamsters are used organ wise. In screening of adenocarcinomas of colon and prostate- rats, transitional cell carcinoma of bladder-mouse and rats, papillomas and squamous cell carcinoma of skin- mouse, epithelial & thecal cell carcinomas of ovary as well as squamous cell carcinomas of oesophagus, head, neck-rats and hamster and for ductal carcinomas of pancreas hamster species can be used.


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