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ORIGINAL ARTICLE
Year : 2020  |  Volume : 8  |  Issue : 3  |  Page : 200-209

Pharmaceutico-analytical standardization and drug dosage modification of Dhatryadi Churna


Department of Rasashastra & Bhaishajya Kalpana, Mahatma Gandhi Ayurveda College, Hospital and Research Centre, Wardha, Maharashtra, India

Correspondence Address:
Dr. Bharat Rathi
Department of Rasashastra & Bhaishajya Kalpana, Mahatma Gandhi Ayurveda College, Hospital and Research Centre, Salod (H), Datta Meghe Institute of Medical Sciences (Deemed to be University) 442107, Wardha, Maharashtra.
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/JISM.JISM_71_20

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Introduction: Churnakriya has been described in Ayurveda classics under the concept of Bhavana Samskara (process of trituration) where the drug in the powder form is triturated with liquid preparations containing the same ingredients to enhance the potency of drug and dose reduction. Considering Churna Kalpana (powdered drug) where the dose is large, Churnakriya concept proves helpful in reducing the dose and enhancing the palatability. Aim: Pharmaceutico-analytical standardization and drug dosage modification of DC (Dhatryadi Churna). Materials and Methods: DV (Dhatryadi Vati) was prepared as described in classics. The Churna was triturated with the decoction of the same ingredients taken in equal proportion. Trituration was continued till 3 days. Classical DC and the DV were analytically studied for organoleptic and various physicochemical properties such as moisture content, ash values, extractive values hardness, friability, and disintegration time, and uniformity of weight. High-performance thin-layer chromatography was also carried out to ascertain the quality, purity, and safety of these herbal formulations. Observations and Results: Standard DV can be prepared from three Bhavana of Dhatryadi Kwatha each Bhavana for average 193.55min, prepared DV will be dark brown color with smell is pleasant and average 557.77g of Bhavita Dhatryadi Churna can be obtained from 506.33g of DC with 10.35% weight gain. Analytical specifications observed for DC and DV were within the acceptable limits mentioned in API so both formulations are of standard quality. Conclusion: Preparation of DV was done in three batches. The trituration period was 3–4h a day for each Bhavana. At the end of Bhavana the product showed all the features of Subhavita Lakshana (signs of proper trituration). The final product yielded 10.35% weight gain.


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