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ORIGINAL ARTICLE
Year : 2021  |  Volume : 9  |  Issue : 1  |  Page : 33-38

Pharmaceutical validation of modified Chitraka Haritaki Avaleha: An ayurveda semisolid dosage form


1 Department of Rasa Shastra and Bhaishjya Kalpana Including Drug Research, IPGT & RA, Jamnagar, Gujarat, India
2 Kaumarbhritya, IPGT & RA, Jamnagar, Gujarat, India

Correspondence Address:
Dr. Sonam Sagar Bhinde
Department of Rasa Shastra and Bhaishjya Kalpana Including Drug Research, IPGT & RA, Jamnagar, Gujarat.
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0976-0016.313695

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Introduction: Chitraka Haritaki Avaleha (CHA) is a well-known Ayurveda preparation recommended in the management of chronic rhinitis, cough, asthma, anorexia, pthisis, and worm infestation. These diseases are more common in children, and, hence, CHA is one of the important formulations used in pediatric patients. However, considering its nonpalatable (bitter astringent) taste along with complexity of confection preparation, it is high time to amend and validate its pharmaceutical process. Aim: To prepare modified CHA and develop standard manufacturing procedures for this modified formulation. Materials and Methods: Five pilot batches with varying proportions of ingredients were prepared to fix the ratio of formulation composition and to make it palatable for children. In these five pilot batches, the proportion of the fifth batch was found to be most acceptable and, hence, the ratio of this batch was kept as a standard formulation based on organoleptic parameters; this procedure was repeated thrice to ensure the process validation. Results: Preparation of confection by the classical method by adding Terminalia chebula Retz. powder in decoction was not palatable for pediatric purpose. Jaggery was increased by 1.5 times, Terminalia chebula Retz. powder was reduced by 50%, and Terminalia chebula Retz. was added. Jaggery (1.5 times) used in condiments gave a desired palatable taste (mild bitter and mild astringent) for children. Conclusion: This modified process can be considered as a standard manufacturing process of CHA, especially for pediatric use.


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