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REVIEW ARTICLES
Contribution of text Rasapaddhati in the history of Indian alchemy: A review
Bharat Rathi, Renu Rathi, Santosh Pusadkar
April-June 2019, 7(2):70-74
DOI:10.4103/JISM.JISM_31_19  
Background: Rasapaddhati is a classical Sanskrit text related to Rasashastra, which mainly deals with metals, minerals, and mercurial preparations flourished during the medieval period to achieve Dehavada (attaining long and healthy life by using mercurial preparations) and Lohavada (conversion of lower metals into precious metals such as gold and silver). Later knowledge of Rasashastra extended to the therapeutic application in various diseases. Rasapaddhati is a fifteenth-century alchemical treatise written by Acharya Bindu comprising the personal experiences of the author in the field of alchemy. Aims and Objectives: This work is a humble attempt to summarize the key features of text Rasapaddhati, its contents, and contribution in the development of Indian alchemy. Materials and Methods: A review of Rasapaddhati was performed on Siddhiprada Hindi commentary by Siddhinandan Mishra and published by Chaukhambha Orientalia in 1987. Results and Conclusion: It is written in Shardulvikridit Chhanda and is completed in 236 verses. The key features of Rasapaddhati include the classifications of minerals, metals, precious stones, description of mercury, and its various processes and 49 herbal and herbomineral formulations with therapeutic applications in various diseases.
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CASE REPORTS
Role of Ayurveda in the management of Apasmara: A case study
Gaurav Sawarkar, Punam Sawarkar
October-December 2019, 7(4):245-248
DOI:10.4103/JISM.JISM_63_19  
Apasmara (epilepsy) is defined by Acharya Charaka as Apagama (deterioration) of Smriti (retention) associated with Bibhatsa Chesta (seizers) due to derangement of Dhi and Sattva. The vitiate Dosha related to the condition are Vata and Rajo Dosha. The main features of Apasmara are impairment in memory or awareness. Even though most of the times, it is considered as Manasrogas (psychic disorders), it is not a Manasroga. Apasmara is one of the diseases, which affects both Sharira (physical) and Manas (mental). A 52-year-old man approached the OPD of Panchakarma department with the impairment of memory in the last 2 years. Earlier he had taken allopathic medicine but he discontinued the medicine due to no significant relief from the adverse effects of the medicines. He was advised with Yoga Basti (enema), Shirodhara (Pouring of medicated oil over head from a distant height), and Nasya (errhine therapy) along with palliative treatment. After 1-month treatment and follow-up, it was observed that the patient was satisfied with treatment and changes in the complaints with improved quality of life. Palliative treatment was advised to the patient for additional.
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Contribution of Ayurveda for the management of Swarabheda: A case study
Manju Mohan, Punam Sawarkar
July-September 2019, 7(3):178-184
DOI:10.4103/JISM.JISM_59_19  
Background: Voice is a means of communicating verbal messages, which serves as a powerful carrier of personality and emotional, educational, and social status. Dysphonia (impaired voice production) is a very common ailment, affecting nearly one-third of the population at some point in their life. Hoarseness of voice can be correlated to Swarabheda in Ayurveda. The management provided by contemporary medicine for this condition is either conservative or surgical in nature, which is cost worthy. Aims and Objectives: The aim of this study was to assess the efficacy of Ayurvedic management of Swarabheda.Materials and Methods: A 35-year-old woman approached to Ayurvedic hospital with complaints of hoarseness of voice and difficulty and pain while deglutition and talking since 1 year. She was diagnosed with Vataj swarabheda and was treated with Panchakarma treatment including Marsha Nasya with Anutaila and Gandusha along with Shamana Chikitsa. The treatment was continued for consecutive 1 month. Results: Hoarseness of voice was assessed after 15 days with the help of Buffalo III Voice Profile and satisfactory outcome was found especially in the quality and loudness of voice, mental strength, and confidence of patient. Conclusion: The collaborative approach of the aforementioned therapy gives symptomatic relief in Swarabheda.
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Role of Khanduchakka (Ehretia laevis) Lepan (local application) in the management of delayed union of metatarsal fracture: A case report
Suraj V Tichkule, Kiran B Khandare, Pooja P Shrivastav
April-June 2019, 7(2):127-130
DOI:10.4103/JISM.JISM_26_19  
Background: The application of Khanduchakka (Ehertia Laevis) Kalka (paste) in the case of Delayed-union of metatarsal fracture is an innovative idea. It is a case report having the fracture of 3rd and 4th metatarsal of right foot. Ehertia Laevis is folklore plant locally known as Khanduchakka used in fracture and wound healing in various forms by the tribal people. In the present case it is used as Lepan (local application). Observation after treatment shows that the Ehertia Laevis is an effective alternative treatment for fracture and delayed union of bones without any complications. Aim: To evaluate healing effect of Khanduchakka Lepan in the management of Delayed union of Metatarsal fracture. Material and Method: In this present case report, the patient with Delayed union of Metatarsal fracture was treated with Khanduchakka Kalka used as local application after all the mandatory investigations and its efficacy was evaluated on the basis of clinical parameters like pain, swelling and fracture healing. Statistical analysis used: 1. Universal Pain Assessment Tool i.e. Visual Analog Scale (VAS) scoring for pain. 2. Swelling was assessed by measuring affected foot circumference in centimeters. 3. American Orthopedic Foot and Ankle Scale (AOFAS) result was calculated. Results: Patient showed significance results in clinical parameters evaluated. He got partial relief within 2 weeks. Conclusion: X-Ray revealed that there was callus formation and the mal-union was slightly aligned just by simply applying Khanduchakka Kalka over a fracture. Visual analog scale used for pain showed before treatment score - 8/10 and after treatment score - 2/10. Circumference of swelling reduced from 33cm to 29cm. AOFAS score was improved from 38/100 to 79/100 points. Therefore it can be concluded that this intervention not only acts as fracture healing but also relieved symptoms of pain and swelling.
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A case report on management of recurrent anal fistula by Nyagrodha Ksheer Sutra
Dhananjay D Deshmukh, Kiran B Khandare, Pooja P Shrivastav
January-March 2019, 7(1):51-55
DOI:10.4103/JISM.JISM_16_19  
Background: Fistula in ano is defined as an inflammatory tract lined by unhealthy granulation tissue having its external opening in the perianal region and internal opening in the anal canal or rectum. In Ayurveda, it can be correlated with Bhagandar (fistula in ano). Various surgical as well as para-surgical treatments are in rage to treat anal fistula but have certain limitations and risk of recurrence. Critical recurrent anal fistula is one among the toughest and rare anal fistula to treat and still stand as a challenge in front of surgeons. Materials and Methods: In this case report, critical recurrent anal fistula is managed by Nyagrodha Ksheer (Latex) Sutra (medicated seton) after all the mandatory investigations, and its efficacy was evaluated on the basis of clinical parameters such as pain, itching, pus discharge, and cutting rate. Results: Patient showed significant results in clinical parameters evaluated. Even after 1-month follow-up assessment, there were no signs of recurrence. Conclusion: As seen in many cases, it is very difficult to manage the anal fistula because of its high recurrence rate. In this case also, it was evident that the patient was having the same complaint of recurrence of fistula after multiple surgeries. In order to find out a minimal invasive technique, an attempt was made to treat the critical recurrent fistula with the help of Nyagrodha Ksheer Sutra. From the aforementioned case, it is concluded that Nyagrodha Ksheer Sutra is efficient in treating critical recurrent anal fistula. It also revealed that Nyagrodha Ksheer acts on the basis of its Shodhan (wound cleaning) and Ropan (wound healing) property to heal critical recurrent anal fistula.
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Proficiency of Khanduchakka Ghrit in the management of Parikartika: A case report
Suraj V Tichkule, Kiran B Khandare, Pooja P Shrivastav
January-March 2019, 7(1):47-50
DOI:10.4103/JISM.JISM_11_19  
Background: Fissure-in-ano is a common anorectal disease. It is mainly of two types: acute and chronic. Chronic fissure-in-ano is difficult to treat and most of the time, it is associated with sentinel tag, which guards the fissure from healing, resulting in nonhealing ulcer, which calls for surgical intervention. Khanduchakka (Ehretia laevis) is a folklore plant that is used popularly by the tribal people for the healing of the nonhealing ulcers. Using that reference in this research work, Khanduchakka Ghrit was used as a local application for managing chronic fissure-in-ano and its efficacy was evaluated. Materials and Methods: In this case report, a patient with chronic fissure-in-ano was treated by Khanduchakka Ghrit, which was used as a local application, after all the mandatory investigations, and its efficacy was evaluated on the basis of clinical parameters such as pain, bleeding, itching, and healing. Results: The patient showed significant results in the clinical parameters evaluated. She got relief in pain, itching, bleeding per rectum, and fissure within 20 days. Even on follow-up assessment, no signs of recurrence were reported. Conclusion: From the aforementioned case, it was concluded that simply applying Khanduchakka Ghrit over a chronic fissure-in-ano is able to heal it. This study revealed that it not only acts as a Ropana (healing agent) but also acts as a Lekhandravya (scrapping agent), which helps in removing slough present at fissure bed and simultaneously helps in the healing of chronic fissure-in-ano.
  1 967 128
EDITORIAL
Approaches for increasing quality of research publications in Ayurveda
Dhirajsingh S Rajput
October-December 2019, 7(4):197-199
DOI:10.4103/JISM.JISM_15_20  
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ORIGINAL ARTICLES
Pharmaceutico-analytical study of Adraka Khanda
Neha S Chavhan, Bharat Rathi
April-June 2019, 7(2):112-118
DOI:10.4103/JISM.JISM_19_19  
Background: Adraka (Zingiber Officinale) Khanda described in Bhaishajya Ratnavali is a drug of choice in Udarda (Pressure Urticaria), Shittapitta (Cold Urticaria) and Koth (Solar Urticaria) such as autoimmune system. This formulation is having spicy test. Khanda being one of the common dosage from appreciated by all age group for their palatability and easy method of administration and feasibility. Pharmaceutical standardization of this formulation is not established yet, which is first step towards research on the formulation. Hence present work was planned. Material and Method: Three batches of Adraka were prepared by adopting reference of Bhaishajya Ratnavali and the average required for preparation of Adraka Khanda was one day. A constant heat of 90 to 100 °C was maintained throughout the procedure. Result and Conclusion: The analytical study revealed average observed values of pH (6.2), Acid insoluble ash (0.50), Moisture content (3.5), Water extract (23.2) Alcoholic extract (20.8), Water soluble ash (4.3) , Total ash (5.2).
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In vivo anticancer activity and toxicity of Ayurveda compound W.S.R. to leukemia
Monika Sharma, Sharad Porte, Sandeep Charak
January-March 2019, 7(1):20-27
DOI:10.4103/JISM.JISM_2_19  
Introduction: A diseased caused by an uncontrolled division of abnormal cells in any tissue of any organ of the body is called cancer. There are various types of cancers on the basis of primary abnormal growth in tissues. Leukemia is a type of cancer of blood, which is caused by the rapid production of abnormal white blood cell. In Ayurveda, the reference of the cancer and blood cancer is found indirectly under the heading of Arbuda (cancer) and Rakta Arbuda (leukemia), respectively. In Ayurveda, there are so many herbo-mineral drugs that are useful in treating cancer. Aims and Objectives:
  1. To study the in vivo anticancer (blood cancer) activity of Ayurveda compound.
  2. To compare the toxicity of Ayurveda compound with injection/tablet arsenic trioxide.
  3. To evaluate, elaborate, and discuss the etiology of leukemia as per Ayurveda.
Materials and Methods: An in vivo study was conducted in Institute of Biomedical and Industrial Research. The in vivo antileukemic effect was carried out by using benzene-induced (carcinogen) model in Swiss albino mice and the acute toxicity study was conducted according to fixed single-dose toxicity. The herbo‑mineral drugs has been prepared by using purified arsenic (arsenic trioxide), Vinca rosea, and Urginia indica to study in vivo anti-leukemic effect and toxicity. This study was conducted according to organisation for economic co-operation and development Guidelines 423 and the antileukemic activity was carried out by benzene-induced leukemia in albino mice after animal ethical clearance. Result: The highest dose of the test drug (2000mg/kg) in the acute toxicity study shows minimal adverse effect of toxicity on liver and no adverse effect was found on kidney and spleen. The result was found better in study group 1 having myelocytic leukemia than study group 2 having lymphocytic leukemia. Conclusion: The effect of study drug shows good antileukemic activity, although standard drug was found better than study drug. Overall, the study was found safe and effective on blood cancer.
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